Assessment of Neuroinflammation in Central Inflammatory Disorders Using [F-18]DPA-714.
Status:
Recruiting
Trial end date:
2021-11-01
Target enrollment:
Participant gender:
Summary
The primary objective of this study is to measure the concentration and the regional brain
distribution of activated brain microglia/macrophages using the PET radiopharmaceutical
[F-18]DPA-714 in individuals with chronic pain and fatigue suspected to be associated with
neuroinflammation. The PET tracer [F-18]DPA-714 binds to the 18 kDa translocator protein
(TSPO, also known as the peripheral benzodiazepine receptor) in the mitochondria of activated
microglia/macrophages and provides a non-invasive measure of neuroinflammation. The primary
objective of this study is to determine if pain and fatigue patients have higher levels of
neuroinflammation than HC individuals as measured with [F-18]DPA-714-PET/MRI.